Xia Wu

Jan 27, 2025 | dx.doi.org | Xia Wu |Ming Cui |Kun Wu |Jun Guo

IntroductionClick to copy section linkSection link copied!Due to their high tunability and expanded photoredox potentials, organo-photocatalysts have recently been widely explored in photoinduced organic transformations.

Jan 27, 2025 | pubs.acs.org | Xia Wu |Ming Cui |Kun Wu |Jun Guo

IntroductionClick to copy section linkSection link copied!Due to their high tunability and expanded photoredox potentials, organo-photocatalysts have recently been widely explored in photoinduced organic transformations.

Dec 30, 2024 | nature.com | Tian Li |Shan Jiang |Yuanhao Dai |Xia Wu |Huihui Guo |Li Ren | +7 more

Marine cyclopianes are a family of diterpenoid with novel carbon skeleton and diverse biological activities. Herein, we report our synthetic and chemical proteomics studies of cyclopiane diterpenes which culminate in the asymmetric total synthesis of conidiogenones C, K and 12β-hydroxy conidiogenone C, and identification of Immunity-related GTPase family M protein 1 (IRGM1) as a cellular target. Our asymmetric synthesis commences from Wieland-Miescher ketone and features a sequential intramolecular Pauson-Khand reaction and gold-catalyzed Nazarov cyclization to rapidly construct the 6-5-5-5 tetracyclic skeleton. The stereocontrolled cyclopentenone construction is further investigated on complex settings to demonstrate its synthetic utility. Furthermore, using an alkyne-tagged conidiogenone C-derived probe, IRGM1, a master regulator of type I interferon responses, is identified as a key cellular target of conidiogenone C responsible for its anti-inflammatory activity. Preliminary mechanism of action studies shows that conidiogenone C activates IRGM1-mediate dysfunctional mitochondria autophagy to maintain mitochondria quality control of inflammatory macrophages. The cyclopiane diterpenoids are a class of complex natural products with unique carbon skeleton and diverse biological activities. Herein, the authors report the total synthesis and chemical proteomics studies of cyclopiane diterpenes which culminate in the asymmetric total synthesis of conidiogenones C, K and 12β-hydroxy conidiogenone C, and identification of Immunity-related GTPase family M protein 1 as a cellular target of conidiogenone C.

Jun 24, 2024 | pubs.rsc.org | Yao Lu |Yutao Zhang |Xia Wu |Ruihua Pu

De Novo Zwitterionic Strategy of Ultra-stable Chemiluminescent Probes: Highly Selective Sensing Singlet Oxygen in FDA-approved Phototherapy Singlet oxygen (1O2), as a fundamental hallmark in photodynamic therapy (PDT), enables ground-breaking clinical treatment in ablating tumors and killing germs.

Dec 18, 2023 | mdpi.com | Xia Wu |Wei Lu

1. IntroductionLet Fq be the finite field with q elements and Fqn the vector space with dimension n over Fq. For a vector v=(v1,…,vn)∈Fqn, let Suppt(v):={1≤i≤n:vi≠0} be the support of v. The Hamming weight of v is wt(v):=#Suppt(v). For any two vectors u,v∈Fqn, if Suppt(u)⊆Suppt(v), we say that v covers u (or u is covered by v) and write u⪯v. Clearly, av⪯v for all a∈Fq. An [n,m]q linear code C over Fq is an m-dimensional subspace of Fqn.