Ximin Zeng

Jun 12, 2023 | frontiersin.org | Ximin Zeng

1. IntroductionCitrobacter is a facultative anaerobic Gram-negative bacteria, which exists widely in nature, such as water, soil and food. Today C. freundii is regarded as an important nosocomial pathogen and is frequently found in patients’ blood, urine, soft tissues, and wounds (Khorasani et al., 2008; Kumar et al., 2013). In some extensive observational studies, Citrobacter accounted for approximately 3–6% of Enterobacteriaceae isolates in clinical settings (Mohanty et al., 2007).

Mar 23, 2023 | cell.com | Sarah Long |APC Microbiome Ireland |Ximin Zeng |Dmitry S. Karlov

Regression models constructionThe binding energy decomposition for the set of mutant enzyme/substrate pairs led to a matrix with dimensions N x M (the number of observations where each observation denotes the relative ability to hydrolyze a specific bile acid by a chosen mutant enzyme vs a number of amino acids in a tetramer), where each cell i, j content represents the interaction energy between j amino acid of i mutant and the substrate.

Feb 23, 2023 | frontiersin.org | Ximin Zeng |Faham Khamesipour |Getahun E. Agga

1. Introduction Antimicrobial therapy is critical for the treatment of bacterial infections in veterinary medicine; however, resistance to these treatments has been increasing for decades (Thanner et al., 2016) and, as a result, there are concerns about the efficacy of antimicrobials in food-producing animals.