Xin-Hua Feng

Jun 10, 2024 | nature.com | Ran Ding |Jinkai Wan |Lei Zhang |Xin-Hua Feng |Junfang Ji |Bin Zhao | +3 more

AbstractRNF214 is an understudied ubiquitin ligase with little knowledge of its biological functions or protein substrates. Here we show that the TEAD transcription factors in the Hippo pathway are substrates of RNF214. RNF214 induces non-proteolytic ubiquitylation at a conserved lysine residue of TEADs, enhances interactions between TEADs and YAP, and promotes transactivation of the downstream genes of the Hippo signaling.

Jan 3, 2024 | nature.com | Bin Zhao |Long Zhang |Xin-Hua Feng

AbstractThe Hippo pathway has important roles in organ development, tissue homeostasis and tumour growth. Its downstream effector TAZ is a transcriptional coactivator that promotes target gene expression through the formation of biomolecular condensates. However, the mechanisms that regulate the biophysical properties of TAZ condensates to enable Hippo signalling are not well understood.