Xiong Pi

2 months ago | cell.com | Alan Hsu |Qingxiang Huang |Xiong Pi |Jianing Fu |Krishnan Raghunathan |Laxman Ghimire | +23 more

1Department of Pathology, PhD Program in Immunology, Harvard Medical School, Boston, MA 02115, USA 2Dana-Farber/Harvard Cancer Center, Boston, MA 02115, USA 3Department of Pathology, Mass General Brigham, Boston, MA 02115, USA 4State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China 5Department of Biological...

Apr 10, 2024 | nature.com | Gang Du |Liam Healy |Liron David |Caitlin Walker |Tarick J. El-Baba |Corinne A. Lutomski | +12 more

AbstractGasdermin D (GSDMD) is the common effector for cytokine secretion and pyroptosis downstream of inflammasome activation and was previously shown to form large transmembrane pores upon cleavage by inflammatory caspases to generate the GSDMD N-terminal domain (GSDMD-NT)1-10. Here we report that GSDMD Cys191 is S-palmitoylated and palmitoylation is required for pore formation.