Xuezhuang Li

Jan 14, 2025 | biorxiv.org | Jianhong Wang |Yifan Kong |Xuezhuang Li |Kun Xiang

AbstractDNA replication fork speed, which controls the rate of genome duplication, has emerged as a key regulator of cellular plasticity. However, its role in neurogenesis remains unexplored. Mini-chromosome maintenance complex (MCMs)-binding protein (MCMBP) functions as a chaperone for newly synthesized MCMs, increasing chromatin coverage to restrain fork speed.

Jan 12, 2025 | biorxiv.org | Jianhong Wang |Yifan Kong |Xuezhuang Li |Kun Xiang

AbstractDNA replication fork speed, which controls the rate of genome duplication, has emerged as a key regulator of cellular plasticity. However, its role in neurogenesis remains unexplored. MCMBP functions as a chaperone for newly synthesized Mini-chromosome maintenance complexes (MCMs), increasing chromatin coverage to regulate fork progression.

Nov 5, 2024 | biorxiv.org | Jianhong Wang |Yifan Kong |Yulian Tan |Xuezhuang Li

AbstractDNA fork speed, the rate of replication fork progression, has emerged as a cellular plasticity regulator, however, for its role in neurogenesis has never been explored before. Here, we show that fork speed was increased as neural progenitors-radial glial cells (RGCs) transition from symmetric to asymmetric divisions.