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Jan 14, 2025 | 
biorxiv.org | Jianhong Wang |Yifan Kong |Xuezhuang Li |Kun Xiang
AbstractDNA replication fork speed, which controls the rate of genome duplication, has emerged as a key regulator of cellular plasticity. However, its role in neurogenesis remains unexplored. Mini-chromosome maintenance complex (MCMs)-binding protein (MCMBP) functions as a chaperone for newly synthesized MCMs, increasing chromatin coverage to restrain fork speed.
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Jan 12, 2025 | 
biorxiv.org | Jianhong Wang |Yifan Kong |Xuezhuang Li |Kun Xiang
AbstractDNA replication fork speed, which controls the rate of genome duplication, has emerged as a key regulator of cellular plasticity. However, its role in neurogenesis remains unexplored. MCMBP functions as a chaperone for newly synthesized Mini-chromosome maintenance complexes (MCMs), increasing chromatin coverage to regulate fork progression.
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Dec 9, 2024 | 
biorxiv.org | Ting Hu |Yifan Kong |Yulian Tan |Pengcheng Ma
AbstractNeocortex expansion has a concerted relationship with folding, underlying evolution of human cognitive functions. However, molecular mechanisms underlying this significant evolutionary process remains unknown. Here, using tree shrew as an outgroup of primates, we identify a new regulator CCNB1IP1, which acquired its expression before the emergence of primates.
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Nov 5, 2024 | 
biorxiv.org | Jianhong Wang |Yifan Kong |Yulian Tan |Xuezhuang Li
AbstractDNA fork speed, the rate of replication fork progression, has emerged as a cellular plasticity regulator, however, for its role in neurogenesis has never been explored before. Here, we show that fork speed was increased as neural progenitors-radial glial cells (RGCs) transition from symmetric to asymmetric divisions.
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Aug 19, 2024 | 
bjournal.org | Junhui Yang |Yunjie Zhang |Yifan Kong |Jiawei Lin
Braz. J. Med. Biol. Res.2024;57:e13661.
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Jun 17, 2024 | 
journals.plos.org | Yifan Kong |Chaohao Li |Jinpeng Liu |Sai Wu
Loading metrics Open Access Peer-reviewedResearch Article Citation: Kong Y, Li C, Liu J, Wu S, Zhang M, Allison DB, et al. (2024) Single-cell analysis identifies PLK1 as a driver of immunosuppressive tumor microenvironment in LUAD. PLoS Genet 20(6): e1011309.
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Dec 27, 2023 | 
sciencedirect.com | Xiaorui Yan |Meng Xie |Yifan Kong |Xiaoguang Duan
With the increasingly serious situation of antibiotic pollution, the degradation of pollutants by semiconductor photocatalysts has attracted extensive attention [1], [2]. Ciprofloxacin (CIP), a widely used fluoroquinolone antibiotic, is frequently detected in the aqueous environment and its removal by conventional wastewater treatment processes is limited, posing a potential threat to the safety of the water environment.
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Sep 19, 2023 | 
biorxiv.org | Yifan Kong |Chaohao Li |Jinpeng Liu |Min Zhang
AbstractPLK1 (Polo-like kinase 1) plays a critical role in the progression of lung adenocarcinoma (LUAD). Recent studies have unveiled that targeting PLK1 improves the efficacy of immunotherapy, highlighting its important role in the regulation of tumor immunity. Nevertheless, our understanding of the intricate interplay between PLK1 and the tumor microenvironment (TME) remains incomplete.
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Aug 5, 2023 | 
biorxiv.org | Yifan Kong |Chaohao Li |Jinpeng Liu |Min Zhang
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