Yasaman Barekatain

Jun 26, 2024 | digitalcommons.library.tmc.edu | Victoria Yan |Yasaman Barekatain |Yu-Hsi Lin |Nikunj Satani

Metabolically labile prodrugs can experience stark differences in catabolism incurred by the chosen route of administration. This is especially true for phosph(on)ate prodrugs, in which successive promoiety removal transforms a lipophilic molecule into increasingly polar compounds.

Jul 25, 2023 | digitalcommons.library.tmc.edu | Yasaman Barekatain

Author ORCID Identifier 0000-0002-4454-1496 Document Type Dissertation (PhD) Program Affiliation Medical Physics Degree Name Doctor of Philosophy (PhD) Advisor/Committee Chair Raghu Kalluri, M.D., Ph.D Committee Member Florian Muller, Ph.D. Committee Member Ronald DePinho, M.D. Committee Member Pratip Bhattacharya, Ph.D Committee Member John de Groot, M.D. Committee Member Jason Huse, M.D., Ph.D Committee Member Yonathan Lissanu, M.D., Ph.D Abstract Homozygous deletion of methylthioadenosine...