Kyu Sik Kim

Nov 6, 2024 | science.org | Yaxiong Shen |Zhenghao Li |Lucía Minarrieta |Kyu Sik Kim

AbstractPhysiological needs evoke motivational drives that produce natural behaviors for survival. In previous studies, the temporally intertwined dynamics of need and motivation have made it challenging to differentiate these two components. On the basis of classic homeostatic theories, we established a normative framework to derive computational models for need-encoding and motivation-encoding neurons.

Jul 25, 2024 | science.org | Giulia Santoni |Natalia Condic |Alice-Agnes Gabriel |Kyu Sik Kim

Editor’s summaryGlucagon-like peptide-1 (GLP-1) plays a pivotal role in signaling the termination of food consumption. GLP-1 receptor agonists are highly successful medications for obesity that are linked to shifts in food cognition, including diminished hypothalamic responses to food cues and alterations in the perception of food palatability in humans. However, the targets of these agonists have not been fully clarified. Kim et al.

Jun 27, 2024 | science.org | Krishnan K Mahadevan |Dawid Zyla |Kyu Sik Kim |Joon Seok Park

AbstractGLP-1 receptor agonists (GLP-1RAs) are effective anti-obesity drugs. However, the precise central mechanisms of GLP-1RAs remain elusive. We administered GLP-1RAs to obese patients and observed heightened sense of preingestive satiation. Analysis of human and mouse brain samples pinpointed GLP-1R neurons in the dorsomedial hypothalamus (DMH) as candidates for encoding preingestive satiation. Optogenetic manipulation of DMHGLP-1R neurons caused satiation.