Yi-Hsin Chan

Apr 16, 2024 | medrxiv.org | Jo-Nan Liao |Yi-Hsin Chan |Hsin-Fu Lee |Yung-Hsin Yeh

The authors have declared no competing interest. This study was supported by grants 105-2628-B-182A-003-MY3 from the Ministry of Science and Technology (MOST 110-2314-B-075-059, MOST 111-2314-B-075-004-MY2) and grants CMRPG3E1681, CMRPG3E1682, CMRPG3E1683, and CORPG3G0351 from Chang Gung Memorial Hospital, Linkou, Taiwan. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Jul 14, 2023 | jbiomedsci.biomedcentral.com | Yi-Hsin Chan |Feng-Chun Tsai |Gwo-Jyh Chang |Ying-Ju Lai |Shang-Hung Chang |Yung-Hsin Yeh | +1 more

In this study, we first demonstrated that CD44 signaling contributes to β-AR-induced activation of RyR2 and PLN through the interaction with Epac1 and activation of CaMKII. Inhibition of CD44 is effective in preventing β-AR-induced Epac1-dependent activation of RyR2 and PLN, which leads to Ca2+ leakage from SR and the subsequent VAs. CD44 is upregulated in HF. Eliminating CD44 is effective in reducing VA inducibility in HF mice.