Yinghan Chen

Nov 26, 2024 | nature.com | Wenyuan Xu |Yinghan Chen |Xin Wang

AbstractHydrogen sulfide (H2S) is an important endogenous gasotransmitter, but the bioorthogonal reaction triggered H2S donors are still rare. Here we show one type of bioorthogonal H2S donors, sydnthiones (1,2,3-oxadiazol-3-ium-5-thiolate derivatives), which was designed with the aid of density functional theory (DFT) calculations. The reactions between sydnthiones and strained alkynes provide a platform for controllable, tunable and mitochondria-targeted release of H2S.

Aug 14, 2024 | arxiv.org | Yinghan Chen |Shizhong Han |Ying Lin

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Aug 13, 2024 | onlinelibrary.wiley.com | Shiyu Wang |Yinghan Chen |Shushan Wu |Luyang Fang

Introduction Given the prevalence of computer-based assessments and the abundance of digital devices, diverse forms of multimodal data, including response times and eye-tracking data, have become more accessible alongside traditional outcome data like response accuracy. A wide array of psychometric models has emerged, utilizing response accuracy and response time for inference, either independently or in combination.