Yongcheng Chen

Aug 22, 2024 | pubs.rsc.org | Fang Liu |Yongcheng Chen |Yue Huang |Qiao Jin

Nanomaterial-based therapeutics for enhanced antifungal therapy The application of nanotechnology in antifungal therapy is gaining increasing attention. Current antifungal drugs have significant limitations, such as severe side effects, low bioavailability, and the rapid development of resistance. Nanotechnology offers an innovative solution to these issues. This review discusses three key strategies of nanotechnology to enhance antifungal efficacy.

Jul 31, 2024 | chemistry-europe.onlinelibrary.wiley.com | Fang Liu |Yongcheng Chen |Yue Huang |Qiao Jin

The increasing severity of fungal infections globally and the limited availability of effective treatments necessitate novel therapeutic strategies. In this study, we developed a copper-polyphenol nanocomplexes (CPE NPs) through a one-step synthetic process by the coordination self-assembly of copper sulfate (CuSO4), protocatechuic acid (PA), and ε-Poly-L-lysine (EPL).

Oct 26, 2023 | pubs.rsc.org | Fang Liu |Yue Huang |Yutong Li |Yongcheng Chen

A heparan sulfate proteoglycan-mimicking AIE fluorescent probe for SARS-CoV-2 detection A heparan sulfate proteoglycan (HSPG)-mimicking fluorescent probe, tetrasulfonated tetraphenylethene (TPES) with aggregation-induced emission (AIE) characteristic is designed for fast SARS-CoV-2 detection. TPES can adhere to SARS-CoV-2 by the strong interaction between sulfonic acid groups of TPES and the spike proteins of SARS-CoV-2, leading to a significant fluorescent enhancement.