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1 month ago | 
pubs.acs.org | B. Timothy Hummer |Jiaqi Yuan |Yue Huang |Meina Liang
MEDI7219 is a bis-lipidated glucagon-like peptide-1 (GLP-1) analog with enhanced systemic circulation time due to increased reversible binding to albumin. It was being developed as an oral formulation to improve glycemic control and body weight loss in patients with Type 2 diabetes. (1,2) Currently, most GLP-1 receptor agonists are administered via subcutaneous (SC) injection. Thus, oral administration of MEDI7219 may provide a better option for patients by increasing compliance and ease-of-use.
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Jan 20, 2025 | 
mdpi.com | Yue Huang |Wenyuan Xu |Yongcheng Ji
1. IntroductionIn recent years, China has witnessed a rising level of urbanization, accompanied by an escalating demand for land resources. During project construction, particularly in the processes of pit excavation and river maintenance, substantial amounts of silt waste are generated. Curing treatment of this waste silt can notably enhance its bearing capacity and facilitate its effective utilization [1].
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Sep 19, 2024 | 
dx.doi.org | Jiaqi Yuan |Hui Tan |Yue Huang |Anton I. Rosenbaum
IntroductionClick to copy section linkSection link copied!Over the past decades, antibody-drug conjugates (ADCs) have become an increasingly important therapeutic modality in the biopharmaceutical industry. Currently, there are 13 approved ADCs, and many more under evaluation in clinical trials. (1) ADCs are designed to improve therapeutic index (TI) by targeted payload delivery to increase efficacy and limit the payload off-target toxicity.
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Sep 19, 2024 | 
pubs.acs.org | Jiaqi Yuan |Hui Tan |Yue Huang |Anton I. Rosenbaum
Analytical ChemistryCite this: Anal. Chem. 2024, XXXX, XXXClick to copy citationCitation copied!. This publication is licensed under CC-BY 4.0 . You are free to share (copy and redistribute) this article in any medium or format and to adapt (remix, transform, and build upon) the material for any purpose, even commercially within the parameters below:Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator.
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Aug 22, 2024 | 
pubs.rsc.org | Fang Liu |Yongcheng Chen |Yue Huang |Qiao Jin
Nanomaterial-based therapeutics for enhanced antifungal therapy
The application of nanotechnology in antifungal therapy is gaining increasing attention. Current antifungal drugs have significant limitations, such as severe side effects, low bioavailability, and the rapid development of resistance. Nanotechnology offers an innovative solution to these issues. This review discusses three key strategies of nanotechnology to enhance antifungal efficacy.
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Aug 18, 2024 | 
mdpi.com | Yue Huang |Zhengli Wang |Jiamin Zhang |Wei Wang
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Jul 31, 2024 | 
pubs.rsc.org | Weihang Li |Minjie Cai |Yihang Yao |Yue Huang
Moisture-resistant and room-temperature self-healing glassy plastic with thiocarbonyl and hyperbranched structure
While glassy plastics capable of self-healing at room temperature have been developed, their reliance on polar supramolecular interactions makes them vulnerable to water vapor. In humid environments, these materials absorb moisture and become plasticized, resulting in decreased mechanical strength and thermal stability.
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Jul 31, 2024 | 
chemistry-europe.onlinelibrary.wiley.com | Fang Liu |Yongcheng Chen |Yue Huang |Qiao Jin
The increasing severity of fungal infections globally and the limited availability of effective treatments necessitate novel therapeutic strategies. In this study, we developed a copper-polyphenol nanocomplexes (CPE NPs) through a one-step synthetic process by the coordination self-assembly of copper sulfate (CuSO4), protocatechuic acid (PA), and ε-Poly-L-lysine (EPL).
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Jul 23, 2024 | 
arxiv.org | Yue Huang |Yixin Liu |Xiang Li |Pan Zhou
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
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Jun 5, 2024 | 
onlinelibrary.wiley.com | Weihang Li |Haitao Wu |Yue Huang |Yihang Yao
Conflict of interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
