Yongchun Zhang

Oct 9, 2024 | science.org | Deborah Carper |Hyun Lee |Nolan Tucker |Yongchun Zhang

AbstractWhile cell fate determination and maintenance are important in establishing and preserving tissue identity and function during development, aberrant cell fate transition leads to cancer cell heterogeneity and resistance to treatment. Here, we report an unexpected role for the transcription factor p63 (Trp63/TP63) in the fate choice of the squamous versus neuroendocrine lineage in esophageal development and malignancy.