Yongqi Huang

Oct 10, 2023 | pubs.rsc.org | Meng Gao |Yongqi Huang

Molecular dynamics simulations revealed topological frustration in the binding-wrapping process of eIF4G with eIF4E Interaction between the cap-binding protein eIF4E and the scaffolding protein eIF4G is essential for the cap-dependent translation initiation in eukaryotes. In the Saccharomyces cerevisiae eIF4G/eIF4E complex, the intrinsically disordered eIF4E-binding domain of eIF4G folds into a bracelet-like structure upon binding to eIF4E.

Sep 6, 2023 | nature.com | Yongqi Huang |Yue Han |Yunfei Liu |Ping Li |Zhengding Su |Junmei Wang | +7 more

AbstractPreventing tau aggregation is a potential therapeutic strategy in Alzheimer’s disease and other tauopathies. Recently, liquid–liquid phase separation has been found to facilitate the formation of pathogenic tau conformations and fibrillar aggregates, although many aspects of the conformational transitions of tau during the phase transition process remain unknown.