Zhengding Su

Sep 6, 2023 | nature.com | Yongqi Huang |Yue Han |Yunfei Liu |Ping Li |Zhengding Su |Junmei Wang | +7 more

AbstractPreventing tau aggregation is a potential therapeutic strategy in Alzheimer’s disease and other tauopathies. Recently, liquid–liquid phase separation has been found to facilitate the formation of pathogenic tau conformations and fibrillar aggregates, although many aspects of the conformational transitions of tau during the phase transition process remain unknown.