YoungHo Kwon

Sep 11, 2024 | nature.com | Sameer Salunkhe |James Daley |Chaoyou Xue |Angela M. Jasper |Wenjing Li |Rahul Mojidra | +8 more

AbstractThe licensing step of DNA double-strand break repair by homologous recombination entails resection of DNA ends to generate a single-stranded DNA template for assembly of the repair machinery consisting of the RAD51 recombinase and ancillary factors1. DNA end resection is mechanistically intricate and reliant on the tumour suppressor complex BRCA1–BARD1 (ref. 2).

Jun 21, 2023 | nature.com | YoungHo Kwon |Maria Jasin |Alexander Taylor |Sandeep Burma |Weixing Zhao |Eric Greene | +1 more

Sung, P. & Klein, H. Mechanism of homologous recombination: mediators and helicases take on regulatory functions. Nat. Rev. Mol. Cell Biol. 7, 739–750 (2006). Article  CAS  PubMed  Google Scholar  Sullivan, M. R. & Bernstein, K. A. RAD-ical new insights into RAD51 regulation. Genes https://doi.org/10.3390/genes9120629 (2018). Meindl, A. et al. Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. Nat. Genet. 42, 410–414 (2010).

Jun 14, 2023 | nature.com | YoungHo Kwon |Patrick Sung

AbstractBreak-induced telomere synthesis (BITS) is a RAD51-independent form of break-induced replication that contributes to alternative lengthening of telomeres1,2. This homology-directed repair mechanism utilizes a minimal replisome comprising proliferating cell nuclear antigen (PCNA) and DNA polymerase-δ to execute conservative DNA repair synthesis over many kilobases.