Youshui Gao

Jun 13, 2024 | nature.com | Peng Ding |Delin Liu |Peng Liao |Minghao Zheng |Youshui Gao |Changqing Zhang | +1 more

AbstractInteractions between osteolineage cells and myeloid cells play important roles in maintaining skeletal homeostasis. Herein, we find that osteolineage cells transfer mitochondria to myeloid cells. Impairment of the transfer of mitochondria by deleting MIRO1 in osteolineage cells leads to increased myeloid cell commitment toward osteoclastic lineage cells and promotes bone resorption.