Yuanhui Liu

Nov 16, 2024 | nature.com | Yuan Wang |Andong Liu |Xianglin Yuan |Yuanhui Liu

AbstractLung adenocarcinoma (LUAD) is the major subtype of lung cancer. The poor prognosis of LUAD patients is attributed primarily to metastasis. ADAMTS16 is a crucial member of the ADAMTS family and is involved in tumor progression. However, its role and regulatory mechanism in LUAD remain unexplored. In this study, ADAMTS16 was identified as a crucial oncogene and survival predictor in LUAD via analyses of public datasets.

Jul 16, 2024 | nature.com | Yuan Wang |Yuanhui Liu |Bo Liu

AbstractImmune checkpoint inhibitors, particularly PD-1/PD-L1 blockades, have been approved for unresectable hepatocellular carcinoma (HCC). However, high resistance rates still limit their efficacy, highlighting the urgent need to understand the underlying mechanisms and develop strategies for overcoming the resistance.