Yuchuan Miao

Feb 27, 2024 | nature.com | Yuchuan Miao

AbstractSegmentation is a fundamental feature of the vertebrate body plan. This metameric organization is first implemented by somitogenesis in the early embryo, when paired epithelial blocks called somites are rhythmically formed to flank the neural tube. Recent advances in in vitro models have offered new opportunities to elucidate the mechanisms that underlie somitogenesis.

Nov 29, 2023 | nature.com | Tatsat Banerjee |Satomi Matsuoka |Debojyoti Biswas |Yuchuan Miao |Dhiman Sankar Pal |Masahiro Ueda | +1 more

AbstractThe plasma membrane is widely regarded as the hub of the numerous signal transduction activities. Yet, the fundamental biophysical mechanisms that spatiotemporally compartmentalize different classes of membrane proteins remain unclear. Using multimodal live-cell imaging, here we first show that several lipid-anchored membrane proteins are consistently depleted from the membrane regions where the Ras/PI3K/Akt/F-actin network is activated.