Satomi Matsuoka

Nov 29, 2023 | nature.com | Tatsat Banerjee |Satomi Matsuoka |Debojyoti Biswas |Yuchuan Miao |Dhiman Sankar Pal |Masahiro Ueda | +1 more

AbstractThe plasma membrane is widely regarded as the hub of the numerous signal transduction activities. Yet, the fundamental biophysical mechanisms that spatiotemporally compartmentalize different classes of membrane proteins remain unclear. Using multimodal live-cell imaging, here we first show that several lipid-anchored membrane proteins are consistently depleted from the membrane regions where the Ras/PI3K/Akt/F-actin network is activated.

Aug 14, 2023 | biorxiv.org | Koji Iwamoto |Satomi Matsuoka |Masahiro Ueda

AbstractExcitable systems of eukaryotic chemotaxis can generate asymmetric signals of Ras-GTP-enriched domains spontaneously to drive random cell migration without guidance cues. The molecules responsible for the spontaneous signal generation remain elusive.