Yuen-Hei Yeung

Sep 14, 2023 | biorxiv.org | Yiquan Wang |Huibin Lv |Ruipeng Lei |Yuen-Hei Yeung

AbstractDespite decades of antibody research, it remains challenging to predict the specificity of an antibody solely based on its sequence. Two major obstacles are the lack of appropriate models and inaccessibility of datasets for model training. In this study, we curated a dataset of >5,000 influenza hemagglutinin (HA) antibodies by mining research publications and patents, which revealed many distinct sequence features between antibodies to HA head and stem domains.