Yuta Yamaguchi

Apr 24, 2023 | nature.com | Yuya Shirai |Yusuke Takeshima |Shuhei Sakakibara |Yuta Yamaguchi |James B. Wing |Daisuke Okuzaki | +1 more

AbstractMechanisms underpinning the dysfunctional immune response in severe acute respiratory syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T and B cell receptors (BCR) of >895,000 peripheral blood mononuclear cells from 73 coronavirus disease 2019 (COVID-19) patients and 75 healthy controls of Japanese ancestry with host genetic data. COVID-19 patients showed a low fraction of nonclassical monocytes (ncMono).