Zechen Wang

Dec 3, 2023 | biorxiv.org | Ran Xu |Yilin Ye |Zechen Wang |Minghui Xin

AbstractDisulfide bonds (SS bonds), covalently formed by sulfur atoms in cysteine residues, play a crucial role in protein folding and structure stability. Due to their significance, artificial disulfide bonds are often introduced to enhance the thermostability of proteins. Although an increasing number of tools can assist with this task, significant amounts of time and resources were often wasted due to inadequate consideration.

Nov 3, 2023 | biorxiv.org | Zechen Wang |Sheng Wang |yangyang Li |Jingjing Guo

AbstractProtein-ligand interaction prediction poses a significant challenge in the field of drug design. Numerous machine learning and deep learning models have been developed to identify the most accurate docking poses of ligands and active compounds against specific targets. However, the current models often suffer from inadequate accuracy and lack practical physical significance in their scoring systems.

Jul 21, 2023 | nature.com | Zechen Wang

AbstractBladder cancer (BC) is one of the most prevalent malignancies worldwide and FGFR3 alterations are particularly common in BC. Despite approval of erdafitinib, durable responses for FGFR inhibitors are still uncommon and most patients relapse to metastatic disease. Given the necessity to discover more efficient therapies for BC, herein, we sought to explore promising synergistic combinations for BC with FGFR3 fusions.