Zheng Zhong

Jul 4, 2024 | mdpi.com | Xu He |Chao Wang |Pan Jia |Zheng Zhong

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Jun 8, 2024 | nature.com | Bei-Bei He |Ying Gao |Zheng Zhong |Song Wu |Wenxuan Zhang |Xiaoyu Tang

AbstractAntimicrobial resistance remains a significant global threat, driving up mortality rates worldwide. Ribosomally synthesized and post-translationally modified peptides have emerged as a promising source of novel peptide antibiotics due to their diverse chemical structures. Here, we report the discovery of new aminovinyl-(methyl)cysteine (Avi(Me)Cys)-containing peptide antibiotics through a synergistic approach combining biosynthetic rule-based omics mining and heterologous expression.

Apr 3, 2024 | science.org | Rohith Teja Mittakola |Ling Deng |Yi Dong |Zheng Zhong

Research ArticleCANCERZheng Zhong https://orcid.org/0000-0003-1614-7798 and David M. Virshup https://orcid.org/0000-0001-6976-850X [email protected] Info & AffiliationsAbstractPathologic Wnt/β-catenin signaling drives various cancers, leading to multiple approaches to drug this pathway. Appropriate patient selection can maximize success of these interventions. Wnt ligand addiction is a druggable vulnerability in RNF43-mutant/RSPO-fusion cancers.

May 8, 2023 | biorxiv.org | Bei-Bei He |Zhuo Cheng |Jing Liu |Zheng Zhong

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