Xiaoyu Tang

Jun 8, 2024 | nature.com | Bei-Bei He |Ying Gao |Zheng Zhong |Song Wu |Wenxuan Zhang |Xiaoyu Tang

AbstractAntimicrobial resistance remains a significant global threat, driving up mortality rates worldwide. Ribosomally synthesized and post-translationally modified peptides have emerged as a promising source of novel peptide antibiotics due to their diverse chemical structures. Here, we report the discovery of new aminovinyl-(methyl)cysteine (Avi(Me)Cys)-containing peptide antibiotics through a synergistic approach combining biosynthetic rule-based omics mining and heterologous expression.

Jan 30, 2024 | arxiv.org | Kang Zeng |Xiaoyu Tang |Jin Wu |Zhuoxu Huang

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