Bei-Bei He

Jun 8, 2024 | nature.com | Bei-Bei He |Ying Gao |Zheng Zhong |Song Wu |Wenxuan Zhang |Xiaoyu Tang

AbstractAntimicrobial resistance remains a significant global threat, driving up mortality rates worldwide. Ribosomally synthesized and post-translationally modified peptides have emerged as a promising source of novel peptide antibiotics due to their diverse chemical structures. Here, we report the discovery of new aminovinyl-(methyl)cysteine (Avi(Me)Cys)-containing peptide antibiotics through a synergistic approach combining biosynthetic rule-based omics mining and heterologous expression.

Nov 13, 2023 | biorxiv.org | Xiaoyong Mo |Bei-Bei He |Nicholas C. Wu

AbstractIron-sulfur (Fe-S) proteins play vital roles in multiple cellular processes, including mediating redox balance as well as DNA replication and repair. Given the role of Fe-S cofactors in genome maintenance, mutations in such metalloproteins could be associated with cancer. Nevertheless, only a few cancer-associated Fe-S proteins have been identified. In vitro, Fe-S cluster is susceptible to degradation in oxic environment.

Sep 28, 2023 | onlinelibrary.wiley.com | Bei-Bei He |Jing J. Liu |Zhuo Cheng |Runze Liu

Introduction Ribosomally synthesized and post-translationally modified peptides (RiPPs) are one of the most expansive families of natural products, possessing a remarkable array of structural diversity and potential for bioactivity.1 These peptides are found in various kingdoms of life, such as plants, fungi, and bacteria.

Sep 28, 2023 | pericles.pericles-prod.literatumonline.com | Bei-Bei He |Jing J. Liu |Zhuo Cheng |Runze Liu

Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.

May 8, 2023 | biorxiv.org | Bei-Bei He |Zhuo Cheng |Jing Liu |Zheng Zhong

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