Zhenwei Zhang

Jul 1, 2024 | onlinelibrary.wiley.com | Zhenwei Zhang |Qi Zhang |Yuxin Hou |Jiali Li

Conflict of interests The authors declare that they have no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.

May 22, 2024 | nature.com | Zhenwei Zhang |VINAY KUMAR |Olexandr Dybkov |Henning Urlaub |Holger Stark

AbstractEarly spliceosome assembly can occur through an intron-defined pathway, whereby U1 and U2 small nuclear ribonucleoprotein particles (snRNPs) assemble across the intron1. Alternatively, it can occur through an exon-defined pathway2,3,4,5, whereby U2 binds the branch site located upstream of the defined exon and U1 snRNP interacts with the 5′ splice site located directly downstream of it.