Zhiyi Chen

Nov 14, 2024 | cell.com | Zhiyi Chen |Alex Inague |Kamini Kaushal |Gholamreza Fazeli |Tasneem Cheytan |Florencio Porto Freitas | +26 more

Keywordsferroptosiscancer metabolismseleniumselenocysteine metabolismcell deathneuroblastomaIntroductionFerroptosis is a non-apoptotic form of cell death characterized by the iron-dependent accumulation of phospholipid hydroperoxides, ultimately leading to membrane rupture and cell death.1 Due to its association with various pathological conditions, including cancer, neurodegeneration, and tissue damage,2 the mechanisms regulating ferroptosis have garnered increasing interest.

Jun 6, 2024 | biorxiv.org | Zhiyi Chen |Alex Inague |Gholamreza Fazeli |Kamini Kaushal

AbstractSelenocysteine (Sec) metabolism is crucial for cellular function and ferroptosis prevention and has traditionally been thought to begin with the uptake of the Sec carrier selenoprotein P (SELENOP). Following uptake, Sec released from SELENOP undergoes metabolisation via selenocysteine lyase (SCLY), producing selenide, a substrate used by selenophosphate synthetase 2 (SEPHS2), which provides the essential selenium donor - selenophosphate - for the biosynthesis of the selenocysteine tRNA.

Apr 30, 2024 | nature.com | Yuhao Chen |Zhen Yuan |Zhiyi Chen

Correction to: Nature Communications https://doi.org/10.1038/s41467-022-31932-x, published online 2 August 2022The original version of the manuscript contained errors in Figure 4 and in the Supplementary Information file. Original Figure 4 has now been replaced with the corrected version in the Article file (PDF and HTML versions) and the revised Supplementary Information file has been made available.

Mar 20, 2023 | blog.apnic.net | Zhiyi Chen

Correctly mapping Autonomous Systems (ASes) to their owner organizations (also called AS2Org mapping) is crucial for Internet researchers. It connects AS-level research and real-world Internet events. For instance, in an Internet censorship event, accurately identifying ASes of government-controlled organizations is the key to discovering which networks conducted censorship (including blocking social media, shutting down mobile services, and so on) and further, estimating those affected.