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Aug 30, 2023 | 
science.org | Annie Chen |Chen Li |Zinan Wang |Dominik Ertel
Published In Science AdvancesVolume 9 | Issue 35September 2023Article versionsSubmission historyReceived: 24 March 2023Accepted: 19 July 2023PermissionsSee the Reprints and Permissions page for information about permissions for this article. AcknowledgmentsFunding: This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 641789 MEDEA.
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Aug 30, 2023 | 
science.org | Annie Chen |Chen Li |Zinan Wang |Jorge Fuenzalida
Published In Science AdvancesVolume 9 | Issue 35September 2023Article versionsSubmission historyReceived: 1 February 2023Accepted: 28 July 2023PermissionsSee the Reprints and Permissions page for information about permissions for this article. AcknowledgmentsWe thank P. Hendra and F. Steinlechner for fruitful discussions. Funding: This work was supported as a Fraunhofer Lighthouse Project (QUILT).
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Aug 30, 2023 | 
science.org | Annie Chen |Chen Li |Zinan Wang |Jiawei Xing
Research ArticleSIGNAL TRANSDUCTION INTRODUCTIONSignal transduction pathways in all living cells detect nutrients, hormones, oxygen, redox potential, and other signals and regulate various cellular functions accordingly. Signals are recognized by receptor proteins via dedicated sensor domains.
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Aug 30, 2023 | 
science.org | Annie Chen |Chen Li |Zinan Wang |Biagio Mandracchia
MATERIALS AND METHODSTo calibrate the pixel-dependent noise of the CMOS cameras (ORCA-Flash-4.0 v3, Hamamatsu) used in this work, we followed the procedure previously reported in (19). Briefly, we recorded a series of dark images (10,000 frames) and then multiple sets of images with different illumination intensities ranging from ~20 to 500 photons per pixel.
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Aug 30, 2023 | 
science.org | Annie Chen |Chen Li |Zinan Wang |Weilian Bao
Published In Science AdvancesVolume 9 | Issue 35September 2023Article versionsSubmission historyReceived: 7 March 2023Accepted: 28 July 2023PermissionsSee the Reprints and Permissions page for information about permissions for this article. AcknowledgmentsWe thank H. Guoqiang for providing Lgr5-EGFP-IRES-creERT2 mouse lines. Funding: This work was supported by the National Natural Science Foundation of China (no. 82130108), National Natural Science Foundation of China (no.
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Aug 30, 2023 | 
science.org | Annie Chen |Chen Li |Zinan Wang |Aaron Shaw
In the U.S., the sentencing of the 2018 Pittsburgh Tree of Life synagogue shooter and the arraignment of the former president for his role in the conspiracy and riots of 6 January 2021 dominated the news in early August 2023. As both incidents were partly inspired, planned, and documented in extremist networks on social media, public reflections about such events should rekindle questions about the role of social media in extremist radicalization in American public life.
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Aug 30, 2023 | 
science.org | Annie Chen |Chen Li |Zinan Wang |Scott T. Keene
Research ArticleAPPLIED PHYSICS INTRODUCTIONMaterials that conduct both electronic and ionic charges through the bulk of their volume are crucial for emerging electrochemical devices (1). Among this materials class, organic mixed ionic-electronic conductors (OMIECs) have emerged as a highly promising candidate due to their biocompatibility and relatively high free volume, which facilitates the uptake of bulky ionic species without undergoing damaging strains.
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Aug 30, 2023 | 
science.org | Annie Chen |Chen Li |Zinan Wang |Roman M. Doll
Research ArticleGENETICS INTRODUCTIONThe manipulation of genes through the induction of precise mutations is a central tool to establish causal genotype-phenotype relationships. Over the last decade, clustered regularly interspaced short palindromic repeats–Cas (CRISPR-Cas) systems have emerged as the preferred system for targeted genome manipulation, mainly due to their high efficiency and ease of use.
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Aug 30, 2023 | 
science.org | Annie Chen |Chen Li |Zinan Wang |Nachuan Song
Published In Science AdvancesVolume 9 | Issue 35September 2023Article versionsSubmission historyReceived: 20 April 2023Accepted: 28 July 2023PermissionsSee the Reprints and Permissions page for information about permissions for this article. AcknowledgmentsFunding: This work was supported by the National Natural Science Foundation of China (grant nos. 22225505 and 22174097). Author contributions: N.S., C.Y., and D.Y. designed the experiments.
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Aug 30, 2023 | 
science.org | Annie Chen |Chen Li |Zinan Wang |Nathaniel Merrill
Published In Science AdvancesVolume 9 | Issue 35September 2023Article versionsSubmission historyReceived: 3 May 2023Accepted: 25 July 2023PermissionsSee the Reprints and Permissions page for information about permissions for this article. AcknowledgmentsThis study is affiliated with the Pacific northwest biomedical Innovation Co-laboratory (PMedIC), a joint research collaboration between OHSU and PNNL. We thank H.
