Articles

  • Mar 13, 2025 | bmcpregnancychildbirth.biomedcentral.com | Juliana Yusof |Siti Hamimah Sheikh Abdul Kadir |Mohd Shahril Ahmad Saman |Nurliana Abd Mutalib

    Polyfluoroalkyl and perfluoroalkyl substances (PFAS) are persistent organic pollutants and exposure have been suggested with the risk of developing preeclampsia. Yet, evidence on the associations of PFAS with preeclampsia is still conflicting. Thus, the current study conducted a systematic review and meta-analysis of the epidemiological evidence linking maternal PFAS exposure to preeclampsia. This research methodology involved searching three electronic databases for epidemiological studies, and then conducting a meta-analysis using a random-effects model to analyse the heterogeneity between the studies. The quality and strength of evidence for each exposure-outcome pair was also evaluated, as well as the risk of bias. The search identified 10 potentially eligible studies related to maternal PFAS blood level with preeclampsia, which 7 were ultimately selected. Meta-analysis demonstrated evidence of association between combined PFAS compounds in pregnant mother with preeclampsia with zero heterogeneity (I2=0.0%, Q= 3.09, df= 6, p=0.798). Preeclampsia was found to have moderate association with maternal perfluorooctanoic acid (PFOA) exposure (Test for overall effect: z=2.2, p=0.03; Test for heterogeneity: I2=0.0%, Q= 3.49, df= 6, p=0.745) as well as maternal perfluorooctane sulfonate (PFOS) exposure (Test for overall effect: z=2.5, p=0.01; Test for heterogeneity: I2=0.0%, Q= 3.70, df= 6, p=0.718). This study showed significant associations between PFOA and PFOS exposure with the risk of preeclampsia. However, in-depth investigation is imperative to elucidate the impact of the different concentration and types of PFAS on preeclampsia risk.

  • Jan 30, 2025 | bmcpregnancychildbirth.biomedcentral.com | Cassandra Yuill |Mairi Harkness |Helen Cheyne |Mónica Ferreira |Eloise Price |Amarnath Bhide | +12 more

    In the United Kingdom, induction of labour rates are rapidly rising, and around a third of pregnant women undergo the procedure. The first stage, cervical ripening, traditionally carried out in hospital, is increasingly offered outpatient – or ‘at home’. The current induction of labour rates place considerable demand on maternity services and impact women’s experiences of care, and at home cervical ripening has been suggested as potential solution for alleviating these. However, there is a lack of evidence on both women’s and birth partners’ experiences and acceptability of at home cervical ripening informing its practice. We undertook a qualitative study of women and their birth partners’ experiences of cervical ripening at home and in hospital. Semi-structured interviews explored experiences, acceptability and consequences of cervical ripening. We identified six key themes: ‘Information and choice’; ‘Physical and sensorial environments’; ‘Pain’; ‘Uncertainty’; ‘Care during induction’; ‘Lasting effects’. Women and birth partners experienced limited choice about cervical ripening. Many reported that shared hospital spaces contributed to negative experiences, while home environments were comforting. Women were unprepared for cervical ripening-associated pain, and delays and uncertainty during induction caused anxiety. Supportive care contributed to more positive experiences; however, some reported difficult or traumatic experiences related to induction. Most participants were positive about home cervical ripening, yet our study highlights the lack of information and genuine choice regarding cervical ripening and induction. Privacy, presence of birth partners and supportive care contributed to more positive experiences among women. Home cervical ripening may be acceptable to some women and birth partners in the context of informed choice and personalised care.

  • Jan 20, 2025 | bmcpregnancychildbirth.biomedcentral.com | Jennifer Leason |Brittany Barker |Yufei Zheng |Harriet MacMillan |Brandi Anne Berry |Erik Mohns | +5 more

    Indigenous Peoples comprise the youngest and fastest growing demographic in Canada, with many living in urban-suburban areas. Given higher fertility rates, younger overall ages and higher adolescent pregnancy rates, perinatal research is needed—to inform policymaking and programming throughout pregnancy and childhood. Yet such data remain scarce in British Columbia (BC), Canada. This study therefore aimed to describe the experiences of young, urban, Indigenous mothers-to-be who enrolled in a larger BC early prevention trial designed to reach families experiencing socioeconomic disadvantage. This descriptive study utilized baseline data from a trial that enrolled first-time mothers-to-be who met indicators of socioeconomic disadvantage and who were residing in select urban-suburban areas. These indicators included being young (19 years or younger) or having limited income, low access to education, and being single (aged 20−24 years). We described and compared survey data on girls (n = 109; aged 14−19 years) and young women (n = 91; aged 20−24 years) using Chi-square or Student’s t-tests. Of the 739 trial participants, 200 or 27% identified as Indigenous and met trial eligibility criteria: limited income (92.9%), limited access to education (67.0%), and/or being single (90.9%). Beyond this, participants reported associated adversities including: unstable housing (63.3%), psychological distress (29.3%), severe anxiety or depression (48.5%), experiences of childhood maltreatment (59.4%) and intimate partner violence (39.5%). Compared to girls, young women reported higher income and educational attainment (p < 0.001), more unstable housing (p = 0.02) and more childhood maltreatment (p = 0.014). Many had recently received primary healthcare (75%), but few had received income assistance (34%). Most (80.5%) reported experiencing four or more adversities. We present data illustrating that a high proportion of pregnant Indigenous girls and young women engaged with public health and consented to long-term research participation—despite experiencing cumulative adversities. The trial socioeconomic screening criteria were successful in reaching this population. Girls and young women reported relatively similar experiences—beyond expected developmental differences in income and education—suggesting that adolescent maternal age may not necessarily infer risk. Our findings underscore the need for Indigenous community-led services that address avoidable adversities starting in early pregnancy.

  • Jan 9, 2025 | bmcpregnancychildbirth.biomedcentral.com | Thomas Vandendriessche |Jill Shawe |Susan Garthus-Niegel |Annick Bogaerts |Dagmar Versmissen |Bieke Bollen | +3 more

    To understand the extent and type of evidence in relation to the effectiveness of intervention strategies targeting working pregnant women, and their partners, for the prevention of mental health problems (depression, anxiety) and improving resilience, from conception until the child is 5 years of age. A scoping review was conducted searching Pubmed (including Medline), Embase, Web of Science Core Collection and Scopus. Inclusion criteria were based on population (employed parents), context (from -9 months to 5 years postpartum) and concept (mental health problems, resilience and prevention/ preventative interventions). Of the 17,699 papers screened, 3 full text papers were included. Studies focused on intervention strategies for working parents which showed a relationship with a reduction in mental health problems (depression and/or anxiety). The intervention strategies extracted from the literature referred to ‘social support’. Social support provided by both the social and the work environment correlated with prenatal stress and depressive symptoms in the postpartum period, and supports a healthy work-family balance. Social support seems to have a positive association with the reduction of mental health problems. However, there are still important gaps in the literature such as a lack of RCT designs to test effectiveness of interventions and systematic reviews. Findings from this study may provide a roadmap for future research to close these gaps in knowledge.

  • Jan 8, 2025 | bmcpregnancychildbirth.biomedcentral.com | Susan Heaney |Clare Collins |Megan Rollo |Leanne Brown |Ellen Payne

    Women and people diagnosed with diabetes in pregnancy, are recommended to have frequent monitoring and careful management for optimal pregnancy outcomes. This health care management should be supported by a multidisciplinary healthcare team. For individuals living in rural areas, there are increased barriers to healthcare access, with subsequent worse health outcomes compared to those in metropolitan regions. Despite this, there remains a lack of research into the experiences of healthcare delivery for rural women and people with diabetes in pregnancy. Survey invitations were sent via the National Diabetes Services Scheme email list. The survey included multiple choice and open-ended questions. Responses from the open-ended question asking participants the changes they would want made to their care delivery were interpreted using qualitative content analysis. Responses were separated into metropolitan and rural categories using the Modified Monash Model criteria. There were 668 survey responses, with 409 responding to the open-ended qualitative survey question/s. 71.6% of respondents were metropolitan and 27.6% lived rurally. A total of 31 codes were established from the open-ended responses, with the five overarching themes of ‘quality of care’, ‘practice & communication’, ‘individual’s experience’, ‘access’ and ‘burden of care’ identified. The most frequently occurring codes irrespective of location included education or information (n = 45), frequency and timeliness of care (n = 42), no changes (n = 42) and improved health professional communication (n = 40). Local care options was the only code with more rural quotes compared to metropolitan. The most frequently occurring codes had strong representation from metropolitan and rural respondents, indicating that those with previous diabetes in pregnancy had similar priorities for changes in their healthcare delivery regardless of location. Rural respondents identifying local care options as a priority for change is likely indicative of the rural healthcare landscape with limited access to care options. Recommendations from this study supported by previous research include focusing on improving health professional communication both with women and people with diabetes in pregnancy and with other relevant professionals. Recommendations for rural locations should focus on improving local care options whilst considering resource limitation, such as telehealth clinics.

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