Renal & Urology News

Renal & Urology News is a digital medical news platform and a monthly printed magazine located in New York City. It provides updates on clinical information specifically for nephrologists and urologists, highlighting insights from medical conferences and articles published in peer-reviewed journals.

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PSMA-Targeted Radioligand Therapies for mCRPC Show Efficacy, Safety, QoL Benefits

1 week ago | renalandurologynews.com | Jessica Nye

PSMA-targeted radioligand therapies (PRLT) for metastatic castration-resistant prostate cancer (mCRPC) decrease PSA levels and improve quality of life (QoL) with infrequent severe toxic events, a meta-analysis and meta-regression published in European Urology concludes. In patients with mCRPC, treatment with lutetium-177 [177Lu]Lu-PSMA has been associated with reductions in PSA levels coupled with improvements in QoL and a favorable safety profile.
COVID-19 May Increase Risk for De Novo CKD and CKD Progression in Children

1 week ago | renalandurologynews.com | natasha persaud

Children infected with SARS-CoV-2 who develop COVID-19 are more likely to experience new onset chronic kidney disease (CKD) and progressive CKD compared with uninfected children, according to findings from a large study. Among 1,900,146 pediatric patients younger than 21 years from 19 medical facilities in the 2020-2023 US National Institutes of Health Researching COVID to Enhance Recovery (RECOVER) initiative, 487,378 children (25.6%) experienced COVID-19.
Guideline-Directed Urodynamics Evaluation Not More Effective for Overactive Bladder

2 weeks ago | renalandurologynews.com | Jessica Nye

The addition of urodynamics investigation to a comprehensive clinical assessment does not improve patient-reported success and is not cost-effective for managing refractory overactive bladder (OAB) or urgency predominant mixed urinary incontinence in women, according to trial findings published in The Lancet.
Favorable PSA Dynamics Indicate Response to ARSI Doublet Therapy in mCSPC

2 weeks ago | renalandurologynews.com | Jessica Nye

Response rates to androgen receptor signaling inhibitors (ARSIs) in metastatic castration-sensitive prostate cancer (mCSPC) are higher among patients achieving an ultra-low PSA nadir, a high PSA response rate, and a longer time in PSA nadir (TTN), a new study finds.
Vanrafia Gets Accelerated Approval for Immunoglobulin A Nephropathy

3 weeks ago | renalandurologynews.com | Jaymin Kang

The Food and Drug Administration (FDA) has granted accelerated approval to Vanrafia® (atrasentan) to reduce proteinuria in adults with primary immunoglobulin A nephropathy (IgAN) at risk of rapid disease progression, generally a urine protein-to-creatinine ratio (UPCR) greater than or equal to 1.5g/g. The pathogenesis of IgAN is believed to be driven by the endothelin (ET)-1 peptide through the ETA receptor.
Neoadjuvant TAR-200 Plus Cetrelimab for MIBC Does Not Worsen Perioperative Outcomes

3 weeks ago | renalandurologynews.com | natasha persaud

Adding neoadjuvant TAR-200 (gemcitabine) intravesical drug release to cetrelimab immune checkpoint inhibition does not worsen perioperative outcomes in patients with muscle-invasive bladder cancer (MIBC). An investigator presented perioperative data from the SUNRISE-4 trial during a game-changing session at the 40th annual European Association of Urology (EAU) Congress in Madrid, Spain.
Active Surveillance Feasible for cT1b Renal Masses in Selected Patients

3 weeks ago | renalandurologynews.com | Jody A. Charnow

Active surveillance may be a feasible option for selected patients with 4.1-7.0 cm renal masses, data presented at the European Association of Urology’s 2025 Congress (EAU25) in Madrid, Spain, suggest. Banna Hussain, DO, MPH, of the Vattikuti Urology Institute at Henry Ford Hospital in Detroit, Michigan, and colleagues studied 1134 patients with cT1b renal masses identified using the Michigan Urological Surgery Improvement Collaborative (MUSIC) kidney registry.
Radical Prostatectomy Improves Cancer-Specific Survival in Oligometastatic Prostate Cancer

3 weeks ago | renalandurologynews.com | natasha persaud

The addition of radical prostatectomy (RP) to best initial systemic therapy reduces the risk of cancer-specific death in men with de novo oligometastatic prostate cancer, an investigator reported at the 40th annual European Association of Urology (EAU) Congress in Madrid, Spain.
Partial Nephrectomy for RCC Offers Best Overall Survival in Older Patients

3 weeks ago | renalandurologynews.com | natasha persaud

Despite its complexity, partial nephrectomy still provides the best survival rates among treatment options in patients aged 75 years or older with T1-T2 renal cell carcinoma (RCC). Investigators reported the findings at the 40th annual European Association of Urology (EAU) Congress in Madrid, Spain. Using the 2004-2019 National Cancer Database, investigators compared oncologic outcomes after ablative and surgical approaches for T1-T2 RCC in 34,121 older patients.
UTI Incidence After Bladder Cancer Surgery Varies by Post-Op Time Point

3 weeks ago | renalandurologynews.com | Jody A. Charnow

The incidence of urinary tract infections (UTIs) following radical cystectomy differs by post-operative time point and patient risk factors, investigators reported at the European Association of Urology’s 40th Congress in Madrid, Spain. Maxwell Sandberg, MD, of Atrium Health, Wake Forest Baptist Medical Center in Winston-Salem, North Carolina, and colleagues retrospectively studied 386 patients who underwent radical cystectomy for bladder cancer from 2012 to 2024.