Therapeutic Delivery

In a fast-paced field, Therapeutic Delivery offers researchers a platform for quickly sharing original research and important reviews on the newest and most relevant advancements. The journal emphasizes the integration of technological, pharmacological, clinical, and physiological factors that contribute to the effective delivery of modern treatments to patients. It presents this vital information in brief, easy-to-read articles that are available to all types of therapeutic delivery researchers.

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Synthesis of 2,4-dihydroxyacetophenone derivatives as potent PDE-1 and -3 inhibitors: in vitro and in silico insights

May 17, 2024 | future-science.com | Aftab Alam |Sana Gul |majid khan |Ahmed A. Elhenawy

MetricsHistoryReceived 29 October 2023 Accepted 8 April 2024 Published online 17 May 2024 Information© 2024 Expert Publishing Science Ltd trading as Taylor & FrancisKeywordsSupplemental materialSupplemental data for this article can be accessed at https://doi.org/10.1080/17568919.2024.2342707AcknowledgmentsAuthors are grateful to the Researchers Supporting Project Number (RSPD2024R1100), King Saud University, Riyadh, Saudi Arabia.
Transitioning from Triton X-100 to Tergitol 15-S-9: impacts on diagnostic assays using viral PCR sample solution | BioTechniques

May 5, 2024 | future-science.com | Azul Zorzoli |Alasdair MacLean |Scott Nicholson |Alison Daniels

The Viral PCR Sample Solution (VPSS) is a liquid formulation created to preserve and transport viral specimens, such as nasopharyngeal swabs in SARS-CoV-2 testing, while also inactivating potential pathogens that might be present in the specimen. It contains Triton X-100 (4-(1,1,3,3-tetramethylbutyl) phenol, ethoxylated), a detergent extensively used in medical diagnostic assays for its ability to release intracellular materials, including nucleic acids [1,2].
Extraterrestrial agriculture: plant cultivation in space

Apr 11, 2024 | future-science.com | Beatrice Bowlby

Cultivating galactic gardensOn Earth, plants follow a developmental plan that relies on the sun and gravitational forces to direct gas and liquid flow essential to plant function [1]. In space, plants find themselves operating completely outside the gravitational and solar rules of terrestrial life. However, as humans explore space and embark on longer missions, there is an emerging need for astronauts to have access to plants for both nutritional and wellbeing reasons.
Chia nanoemulsion: anti-inflammatory mechanism, biological behavior and cellular interactions

Mar 12, 2024 | future-science.com | Lin Zhu |Luana Barbosa Correa |Natália Cristina Gomes-da-Silva |Prapanna Bhattarai

Papers of special note have been highlighted as:• of interest• None . Illuminating an Invisible Epidemic: A Systemic Review of the Clinical and Economic Benefits of Early Diagnosis and Treatment in Inflammatory Disease and Related Syndromes . [Internet]. 8(4), ( ). Available from: /pmc/articles/PMC6518102/. • None . Anti-inflammatory potential of chia seeds oil and mucilage against adjuvant-induced arthritis in obese and non-obese rats . [Internet]. 31(4), ( ). [Internet]. 31(4), ().
Revolutionizing depression diagnosis: earwax analysis for cortisol and beyond

Feb 28, 2024 | future-science.com | Shahzaib Samad |Bilqees Baloch |Muhammad Qadeer

The authors have no financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Age is just a number: can proteomic analysis provide insight into the aging body?

Feb 22, 2024 | future-science.com | Jenny Straiton

Aging; whether you embrace it and age with grace or attempt to turn back the clock with skincare products, for most of us it's inevitable (and preferable to the alternative). With each passing year comes a cake with an ever-increasing number of candles, each of which documents your existence for another rotation around the sun. Our chronological age is linear, a measure of the time we have lived on earth that increases year on year until we die; but what about biological age?
Vaping epidemic among the youth in Pakistan: urgent measures required to combat the rising trend

Feb 14, 2024 | future-science.com | Muhammad Qadeer |Shahzaib Samad |Bilqees Baloch

The history of the vape device, also known as an electronic cigarette, dates back to its manufacture in Beijing in 2003, followed by its introduction to the US market in 2007 [1]. The device operates using a lithium battery, a heating coil, and a reservoir for liquid chemicals, which deliver a controlled dose of nicotine in vapor form [1]. Nicotine, a catecholamine with sympathomimetic effects, rapidly enters the bloodstream and crosses the blood–brain barrier within seconds when inhaled [2].
Clinical approach and utilizing liquid biopsies to interrogate suspected acquired resistance to PD-1 blockade

Jan 31, 2024 | future-science.com | Jia Luo

PD-1 blockade is now routine for nearly all patients with non-small lung cancer. However, the proper investigation of alternative explanations and the cause remains not intuitive for many clinicians. We present a case of a patient who benefitted from PD-1 blockade for more than a year, but later developed what was initially suspected to be radiological progression.
Emerging therapeutic approaches of SHP2-targeted modulators

Jan 26, 2024 | future-science.com | Xinyu Yang |Jinbo Xiong |Bin Yu |Yihui Song

This work is supported by the Natural Science Foundation of China (Nos. 32371317, 22277110 and 82104279), ‘Chunhui Plan’ Cooperative Scientific Research Project of the Ministry of Education (No. HZKY20220280), Natural Science Foundation of Henan Province (Nos. 222300420069 and 222301420049).
Statin use is not associated with inflammation among Chilean women of Mapuche and non-Mapuche ancestry with gallstones

Jan 11, 2024 | future-science.com | Sarah Jackson |Allan Hildesheim |Marina Lex |Paz Cook

Gallbladder cancer (GBC) is a rare, but lethal cancer with a median survival rate of >1 year [1]. Chile has one of the highest GBC incidences in the world with 5.6 per 100,000 [2]. GBC incidence and mortality in Chile is highest for women of Amerindian ancestry, particularly Mapuche women [1,3]. Gallbladder disease is the primary risk factor for GBC resulting in a chronic pro-inflammatory state [4].

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Therapeutic Delivery

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Articles

Synthesis of 2,4-dihydroxyacetophenone derivatives as potent PDE-1 and -3 inhibitors: in vitro and in silico insights

Transitioning from Triton X-100 to Tergitol 15-S-9: impacts on diagnostic assays using viral PCR sample solution | BioTechniques

Extraterrestrial agriculture: plant cultivation in space

Chia nanoemulsion: anti-inflammatory mechanism, biological behavior and cellular interactions

Revolutionizing depression diagnosis: earwax analysis for cortisol and beyond

Age is just a number: can proteomic analysis provide insight into the aging body?

Vaping epidemic among the youth in Pakistan: urgent measures required to combat the rising trend

Clinical approach and utilizing liquid biopsies to interrogate suspected acquired resistance to PD-1 blockade

Emerging therapeutic approaches of SHP2-targeted modulators

Statin use is not associated with inflammation among Chilean women of Mapuche and non-Mapuche ancestry with gallstones

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