David Heisler

Nov 9, 2024 | mdpi.com | David Heisler |Elena Kudryashova |Regan Hitt |Blake Williams

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Jul 2, 2024 | biorxiv.org | David Heisler |Elena Kudryashova |Regan Hitt |Blake Williams

AbstractCompetition between bacterial species is a major factor shaping microbial communities. In this work, we explored the hypothesis that competition between bacterial pathogens can be mediated through antagonistic effects of bacterial effector proteins on host systems, particularly the actin cytoskeleton.

May 16, 2024 | journals.plos.org | Aaron Embry |Nina S. Baggett |David Heisler |Addison White |PLOS Pathogens

DiscussionOur study illustrates the utility of using abortive virus infections as a screening tool to identify IEPs and the host immunity factors they target. From this work, we identify a variety of bacterially-encoded proteins capable of rescuing individual arbovirus infections, as well as six that are capable of rescuing all four viruses screened.

May 16, 2024 | journals.plos.org | Aaron Embry |Nina S. Baggett |David Heisler |Addison White |PLOS Pathogens

DiscussionOur study illustrates the utility of using abortive virus infections as a screening tool to identify IEPs and the host immunity factors they target. From this work, we identify a variety of bacterially-encoded proteins capable of rescuing individual arbovirus infections, as well as six that are capable of rescuing all four viruses screened.

Jan 30, 2024 | biorxiv.org | Aaron Embry |David Heisler |Addison White |Benjamin L. Kocsis

AbstractArboviruses are a diverse group of insect-transmitted pathogens that pose global public health challenges. Identifying evolutionarily conserved host factors that combat arbovirus replication in disparate eukaryotic hosts is important as they may tip the balance between productive and abortive viral replication, and thus determine virus host range.