Adam Orr

Mar 22, 2024 | cell.com | Adam Orr |Anna Orr

The mechanisms by which astrocytes regulate various types of disease processes and neural impairments are incompletely understood. When and how do astrocytes engage in different pathological cascades, synaptic alterations, and neural circuit dysfunctions?

Oct 18, 2023 | biorxiv.org | Neal Bennett |Megan Lee |Adam Orr |Ken Nakamura

AbstractRespiratory chain dysfunction can decrease ATP and increase reactive oxygen species (ROS) levels. Despite the importance of these metabolic parameters to a wide range of cellular functions and disease, we lack an integrated understanding of how they are differentially regulated. To address this question, we adapted a CRISPRi- and FACS- based platform to compare the effects of respiratory gene knockdown on ROS to their effects on ATP.