Adrian S. Woolf

Mar 18, 2024 | nature.com | Xiaoguang Xu |Chachrit Khunsriraksakul |James M. Eales |David Talavera |Lida Wang |Abigail C. Lay | +8 more

AbstractGenetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-specific epigenomic annotations and 3D genome information we generated and validated gene expression prediction models for the purpose of transcriptome-wide association studies in 700 human kidneys. We identified 889 kidney genes associated with BP of which 399 were prioritised as contributors to BP regulation.

Dec 6, 2023 | obgyn.onlinelibrary.wiley.com | Kelly Reilly |Adrian S. Woolf |Natalie Chandler |Sarah Sonner

1 INTRODUCTION Urinary tract malformations (UTMs), also known as congenital anomalies of the kidney and urinary tract (CAKUT),1, 2 account for up to 20% of all major congenital anomalies and affect around 1:1000 births.3 UTMs comprise a wide spectrum of individual disorders including kidney malformations that themselves are divided into agenesis, when the kidney fails to form, and dysplasia, when the organ begins to form but its internal structure is immature and metaplastic.4, 5 The...