Shouneng Peng

Sep 12, 2024 | nature.com | Sizhao Lu |Yang Xu |Shouneng Peng |Adrien Georges |Aya Nomura-Kitabayashi |Robert Wiener | +5 more

AbstractFibromuscular dysplasia (FMD) is a poorly understood disease affecting 3–5% of adult females. The pathobiology of FMD involves arterial lesions of stenosis, dissection, tortuosity, dilation and aneurysm, which can lead to hypertension, stroke, myocardial infarction and even death. Currently, there are no animal models for FMD and few insights as to its pathobiology.

Mar 5, 2024 | biorxiv.org | Shouneng Peng |Erming Wang |Minghui Wang |Xusheng Wang

AbstractINTRODUCTION: The interconnection between brain aging and Alzheimer's disease (AD) remain to be elucidated. METHODS: We investigated multi-omics (transcriptomics and proteomics) data from multiple brain regions (i.e., the hippocampus (HIPP), prefrontal cortex (PFC), and cerebellum (CRBL)) in cognitively normal individuals. RESULTS: We found that brain samples could be divided into ADL (AD-like) and NL (normal) subtypes which were correlated across brain regions.