Aki S Havulinna

Aug 13, 2024 | nature.com | Louise Grahnemo |Pekka Jousilahti |Veikko Salomaa |Aki S Havulinna

AbstractThe gut microbiota (GM) can regulate bone mass, but its association with incident fractures is unknown. We used Cox regression models to determine whether the GM composition is associated with incident fractures in the large FINRISK 2002 cohort (n = 7043, 1092 incident fracture cases, median follow-up time 18 years) with information on GM composition and functionality from shotgun metagenome sequencing.

Mar 24, 2024 | nature.com | Yang Liu |Scott Ritchie |Karin Verspoor |Veikko Salomaa |Aki S Havulinna |Guillaume Meric

AbstractMultiomics has shown promise in noninvasive risk profiling and early detection of various common diseases. In the present study, in a prospective population-based cohort with ~18 years of e-health record follow-up, we investigated the incremental and combined value of genomic and gut metagenomic risk assessment compared with conventional risk factors for predicting incident coronary artery disease (CAD), type 2 diabetes (T2D), Alzheimer disease and prostate cancer.

Feb 29, 2024 | nature.com | Youwen Qin |Aki S Havulinna |Scott Ritchie |Alex Tokolyi |Yoshiki Vázquez-Baeza |Susan Cheng | +2 more

Correction to: Nature Genetics https://doi.org/10.1038/s41588-021-00991-z, published online 3 February 2022. In the version of the article initially published, the descriptions of two FUT2 genotypes were inverted. In Fig. 4c and Extended Data Fig. 7b and their legends, “rs601338:GG/GA” and “rs601338:AA” previously read “rs601338:AG/AA” and “rs601338:GG”, respectively.

Oct 18, 2023 | nature.com | Qiyun Zhu |Donovan H. Parks |Mads Albertsen |Philip Hugenholtz |Andrew Bartko |Aki S Havulinna | +2 more

Correction to: Nature Biotechnology https://doi.org/10.1038/s41587-023-01845-1, published online 27 July 2023. In the version of the article initially published, a portion of the Competing interests statement was missing: “R.K. is a scientific advisory board member, and consultant for BiomeSense, Inc., has equity and receives income.

Jul 27, 2023 | nature.com | Qiyun Zhu |Donovan H. Parks |Mads Albertsen |Philip Hugenholtz |Andrew Bartko |Aki S Havulinna | +2 more

AbstractStudies using 16S rRNA and shotgun metagenomics typically yield different results, usually attributed to PCR amplification biases. We introduce Greengenes2, a reference tree that unifies genomic and 16S rRNA databases in a consistent, integrated resource.