Pekka Jousilahti

Aug 13, 2024 | nature.com | Louise Grahnemo |Pekka Jousilahti |Veikko Salomaa |Aki S Havulinna

AbstractThe gut microbiota (GM) can regulate bone mass, but its association with incident fractures is unknown. We used Cox regression models to determine whether the GM composition is associated with incident fractures in the large FINRISK 2002 cohort (n = 7043, 1092 incident fracture cases, median follow-up time 18 years) with information on GM composition and functionality from shotgun metagenome sequencing.

Aug 1, 2024 | mdpi.com | Ville Vartiainen |Pekka Jousilahti |Jaakko Tuomilehto |Tiina Laatikainen

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Mar 6, 2024 | nature.com | Minna K. Karjalainen |Eeva Sliz |Elias Allara |Weihua Zhang |Pekka Jousilahti |Kati Kristiansson | +46 more

AbstractGenome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1,2,3,4,5,6,7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8,9,10,11.

Feb 17, 2023 | heart.bmj.com | Christin S. Börschel |Alfredo Ortega-Alonso |Aki S Havulinna |Pekka Jousilahti

DiscussionWe evaluated the association of 46 circulating cytokines with incident AF using multiplex techniques in this proteomics approach. Elevated levels of MIP-1β, HGF, CRP and NT-proBNP initially were related to incident AF. However, more refined risk factor-adjusted analyses did not reveal any other biomarker to predict the development of AF besides NT-proBNP.