-
2 months ago | 00272-7&sz=64)
cell.com | Saravanan Raju |Sathvik Palakurty |Alan Sariol |Ngan Wagoner |Lucas Adams |Sean Hui | +3 more
Keywords alphavirus receptor structure pathogenesis therapy cryoelectron microscopy Introduction Alphaviruses are arthropod-transmitted viruses that infect many vertebrate hosts.1 The encephalitic alphaviruses, including Eastern equine encephalitic virus (EEEV), Venezuelan equine encephalitic virus (VEEV), and Western equine encephalitic virus (WEEV), are neurotropic in both horses and humans and cause lethality or long-term neurological sequelae.2 Whereas some bird species serve as enzootic...
-
Mar 12, 2025 | 
nyra.nyc | Lucas Adams
As a senior editor at New York Review Books, I admit that I’m not an expert on buildings. But as the editor of the NYRB’s comics imprint, I do consider myself proficient in assessing rat drawings. In 2015, upwards of six to ten people sent me the pizza rat video with comments along the lines of “you should see this” because I talked about rats a lot, both in real and cartoon form.
-
Feb 22, 2025 | 
nybooks.com | Edward Gorey |Lucas Adams
Hidden away in the Review’s archives were eleven panels of an unfinished serial comic, Les Mystères de Constantinople.
-
Oct 5, 2024 | 01160-4&sz=64)
cell.com | Alan Sariol |Lucas Adams |Sean Whelan |Camille Carmona
KeywordsReceptoralphaviruspathogenesisdecoytherapytropismResearch topic(s)CP: MicrobiologyCP: ImmunologyIntroductionAlphaviruses are arthropod-transmitted, enveloped, positive-strand RNA viruses that cause musculoskeletal disease or encephalitis in humans.
-
Jul 4, 2024 | 
modernfarmer.com | Lucas Adams
In the early 1940s William George Pope, and his wife Mildred “Moodie” Pope, left Utica, NY and bought a farm. They named it High Acres, and started raising Ayeshire Cattle. Pope had been an engineering teacher up to this point in his life, but his passion for High Acres is made clear in the daily journals he kept.
-
Jan 3, 2024 | 
nature.com | Hongming Ma |Lucas Adams |Daved H. Fremont
AbstractMembers of the low-density lipoprotein receptor (LDLR) family, including LDLRAD3, VLDLR, and ApoER2, were recently described as entry factors for different alphaviruses. However, based on studies with gene edited cells and knockout mice, blockade or abrogation of these receptors does not fully inhibit alphavirus infection, indicating the existence of additional uncharacterized entry factors.
-
Jan 3, 2024 | 01318-1&sz=64)
cell.com | Lucas Adams |Douglas Reed |William B. Klimstra |Michael Diamond
These cookies are necessary for the website to function and cannot be switched off in our systems. They are usually only set in response to actions made by you which amount to a request for services, such as setting your privacy preferences, logging in or filling in forms. You can set your browser to block or alert you about these cookies, but some parts of the site will not then work. These cookies do not store any personally identifiable information.
-
Dec 22, 2023 | 00260-0&sz=64)
cell.com | Saravanan Raju |Lucas Adams |Michael Diamond |Immunotherapy Programs
Highlights Proteinaceous receptors bind distinct sites of the alphavirus glycoprotein to mediate efficient cellular entry. The cleft formed by E1–E2 heterodimers is utilized by the mammalian MXRA8 to bind Chikungunya virus (CHIKV) and LDLRAD3 to bind Venezuelan equine encephalitis virus (VEEV).
-
Nov 30, 2023 | 00499-8&sz=64)
cell.com | Lucas Adams |Laura A. VanBlargan |Rita E. Chen |Bradley Whitener
Highlights•NTD mAbs block SARS-CoV-2 infection at a post-attachment step•SARS2-57 mAb recognizes most variants and confers Fc-mediated protection in mice•Cryo-EM reveals SARS2-57 binds loops N3 and N5 of the NTD supersite•Cryo-EM reveals the basis of SARS2-57 variant recognition and immune evasionSummaryMost neutralizing anti-SARS-CoV-2 monoclonal antibodies (mAbs) target the receptor binding domain (RBD) of the spike (S) protein.
-
Nov 15, 2023 | 
biorxiv.org | Lucas Adams |Saravanan Raju |Hongming Ma |Theron Gilliland
AbstractThe very low-density lipoprotein receptor (VLDLR) is comprised of eight LDLR type A (LA) domains and supports entry of distantly related Eastern equine encephalitis (EEEV) and Semliki Forest (SFV) alphaviruses. Here, by resolving multiple cryo-electron microscopy structures of EEEV-VLDLR complexes and performing mutagenesis and functional studies, we show that EEEV uses multiple sites (E1/E2 cleft and E2 A domain) to engage different LA domains simultaneously.
