Alex Mentzer
Featured in: 
nature.com
Articles
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1 month ago |
nature.com | Martin Little |Orion Tong |Bo Sun |Lea Cohen |James Gilchrist |Alex Mentzer | +3 more
AbstractCytomegalovirus (CMV) is a globally endemic latent herpes virus that profoundly impacts T cell immunity. We investigated the oncological consequences of CMV infection across 341 prospectively recruited patients receiving immune checkpoint blockade (ICB) for melanoma. CMV+ patients with metastatic melanoma (MM) have higher lymphocyte counts, reduced neutrophil to lymphocyte ratio and divergent CD8+ T cell gene expression.
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