Alex Mentzer

2 months ago | nature.com | Martin Little |Orion Tong |Bo Sun |Lea Cohen |James Gilchrist |Alex Mentzer | +3 more

AbstractCytomegalovirus (CMV) is a globally endemic latent herpes virus that profoundly impacts T cell immunity. We investigated the oncological consequences of CMV infection across 341 prospectively recruited patients receiving immune checkpoint blockade (ICB) for melanoma. CMV+ patients with metastatic melanoma (MM) have higher lymphocyte counts, reduced neutrophil to lymphocyte ratio and divergent CD8+ T cell gene expression.