Orion Tong

2 months ago | nature.com | Martin Little |Orion Tong |Bo Sun |Lea Cohen |James Gilchrist |Alex Mentzer | +3 more

AbstractCytomegalovirus (CMV) is a globally endemic latent herpes virus that profoundly impacts T cell immunity. We investigated the oncological consequences of CMV infection across 341 prospectively recruited patients receiving immune checkpoint blockade (ICB) for melanoma. CMV+ patients with metastatic melanoma (MM) have higher lymphocyte counts, reduced neutrophil to lymphocyte ratio and divergent CD8+ T cell gene expression.

Nov 6, 2024 | biorxiv.org | Esther Ng |Orion Tong |Chelsea Taylor |Robert Watson

AbstractCD8+ T cells play a central role in the cancer response to immune checkpoint blockade (ICB) treatment, with activity predicated upon antigen recognition by the associated T cell receptor (TCR) repertoire. The contribution of genetic variation to this in cancer treatment is under-explored.