Martin Little

2 months ago | nature.com | Martin Little |Orion Tong |Bo Sun |Lea Cohen |James Gilchrist |Alex Mentzer | +3 more

AbstractCytomegalovirus (CMV) is a globally endemic latent herpes virus that profoundly impacts T cell immunity. We investigated the oncological consequences of CMV infection across 341 prospectively recruited patients receiving immune checkpoint blockade (ICB) for melanoma. CMV+ patients with metastatic melanoma (MM) have higher lymphocyte counts, reduced neutrophil to lymphocyte ratio and divergent CD8+ T cell gene expression.

Oct 9, 2024 | medrxiv.org | Martin Little |Robert Watson |Gusztav Milotay |Dylan Muldoon

The authors have declared no competing interest. Funding BPF is funded by a Wellcome Career Development Award (226535/Z/22/Z) and the study was previously funded by a Wellcome Intermediate Clinical Fellowship to BPF (201488/Z/16/Z) PK is funded by a Wellcome Discovery Award 222426/Z/21/Z and PK and BPF are recipients of a CRUK programme grant DRCNPG-Nov22/100005 - Defining the role of MAIT cells in Cancer Immunotherapy. GM is a DPhil student whose fees have been covered by Etcembly.