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Jan 13, 2025 | 
science.org | Harrison J. Ostridge |Arindam Ghosh |Anqi Wei |Zehao Zhang
AbstractTo elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, sexes, and genotypes. This comprehensive dataset reveals more than 3,000 unique cellular states and over 200 aging-associated cell populations. Our panoramic analysis uncovered organ-, lineage-, and sex-specific shifts of cellular dynamics during lifespan progression.
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Jan 13, 2025 | 
science.org | Harrison J. Ostridge |Arindam Ghosh |Anqi Wei |Alexander Carver
AbstractMaintaining genome integrity is an essential and challenging process. RAD51 recombinase, the central player of several crucial processes in repairing DNA and protecting genome integrity, forms filaments on DNA, which are tightly regulated. One of these RAD51 regulators is FIGNL1, that prevents persistent RAD51 foci without or after DNA damage and genotoxic chromatin association in cells.
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Jan 13, 2025 | 
science.org | Harrison J. Ostridge |Arindam Ghosh |Anqi Wei |Yutao Li
AbstractProkaryotes have evolved diverse defense strategies against viral infection, such as foreign nucleic acid degradation by CRISPR-Cas systems and DNA/RNA synthesis inhibition via nucleotide pool depletion.
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Jan 9, 2025 | 
dx.doi.org | Harrison J. Ostridge |Arindam Ghosh |Anqi Wei |Anran Zhao
Published In ScienceVolume 387 | Issue 673010 January 2025Article versionsSubmission historyReceived: 27 May 2024Accepted: 8 November 2024Published in print: 10 January 2025PermissionsRequest permissions for this article. AcknowledgmentsWe thank S. Qiu (Arizona State University, USA), B. Li (Sun Yat-Sen University, China), and W. Wang (The Fourth Military Medical University, China) for reading the manuscript; Y.
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Jan 9, 2025 | 
science.org | Harrison J. Ostridge |Arindam Ghosh |Anqi Wei |Alexandre Orthwein
Information & AuthorsInformationPublished In ScienceVolume 387 | Issue 673010 January 2025CopyrightCopyright © 2025 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Article versionsSubmission historyPublished in print: 10 January 2025PermissionsRequest permissions for this article.
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Jan 9, 2025 | 
science.org | Harrison J. Ostridge |Arindam Ghosh |Anqi Wei |Collin M. Schohn
Editor’s summaryFuture rises in sea level will depend primarily on the rate at which the Antarctic and Greenland ice sheets discharge their ice into the sea, and that rate depends critically on the flow properties of the temperate ice that exists near the beds and within the margins of the fastest-flowing ice streams. Schohn et al. present results from the world’s largest ice-deformation apparatus revealing how shear deformation in temperate ice occurs.
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Jan 9, 2025 | 
science.org | Harrison J. Ostridge |Arindam Ghosh |Anqi Wei |Francesca Lanzarini
Editor’s summaryMost of our understanding of the neuronal organization underlying natural behaviors in primates derives from experiments in restrained settings. Whether these constraints affect brain activity—and, if they do, how—is unclear. Lanzarini et al. developed a wireless system for recording neurons in the premotor cortex while monkeys performed natural actions in both restrained and freely moving conditions.
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Jan 9, 2025 | 
science.org | Harrison J. Ostridge |Arindam Ghosh |Anqi Wei |Yi Ren
Editor’s summaryMembranes with high selectivity for complex hydrocarbon mixtures and high permeability can potentially reduce the energy footprint of the chemical industry. Ren et al. describe the development of a family of aryl amine polymers with pendent fluorocarbon side chains for organic solvent reverse osmosis. The authors synthesized fluorine containing poly(arylene amine) polymers to fabricate supported thin-film composite membranes with a thickness of 0.2 to 0.3 micrometers.
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Jan 9, 2025 | 
science.org | Harrison J. Ostridge |Arindam Ghosh |Anqi Wei |Christopher Bataille
Building materials such as cement and concrete aggregates could be used to capture and store a large amount of atmospheric CO2. PHOTO: JUNG GETTY/GETTY IMAGESAccording to current climate science, global temperatures will continue to rise until net carbon dioxide (CO2) emissions reach zero (1)—that is, when the amount of CO2 added to the atmosphere is balanced by the amount removed.
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Jan 9, 2025 | 
science.org | Harrison J. Ostridge |Arindam Ghosh |Anqi Wei |Stephen Fletcher
The lack of consensus at the United Nations (UN) global plastics treaty negotiations in December may seem like a setback, but declaring the talks a failure is premature. The process has not collapsed but has been extended, with further negotiations anticipated in 2025. This offers a crucial opportunity for the scientific community to assert its role in shaping a robust, evidence-based agreement to address the global plastic pollution crisis.
