Toni Delorey

3 weeks ago | nature.com | Brian Lin |Atharva Bhagwat |Isha Monga |Ke Xu |Danielle Dionne |Peiwen Cai | +5 more

AbstractHuman airways contain specialized rare epithelial cells including CFTR-rich ionocytes that regulate airway surface physiology and chemosensory tuft cells that produce asthma-associated inflammatory mediators. Here, using a lung cell atlas of 311,748 single cell RNA-Seq profiles, we identify 687 ionocytes (0.45%). In contrast to prior reports claiming a lack of ionocytes in the small airways, we demonstrate that ionocytes are present in small and large airways in similar proportions.

Apr 17, 2024 | nature.com | Jiarui Ding |John Garber |Grace Carter |Toni Delorey |Orit Rozenblatt-Rosen |Daniel Graham | +2 more

AbstractCoordinated cell interactions within the esophagus maintain homeostasis, and disruption can lead to eosinophilic esophagitis (EoE), a chronic inflammatory disease with poorly understood pathogenesis. We profile 421,312 individual cells from the esophageal mucosa of 7 healthy and 15 EoE participants, revealing 60 cell subsets and functional alterations in cell states, compositions, and interactions that highlight previously unclear features of EoE.

Jun 21, 2023 | nature.com | Yoon-Chul Kye |Elena Torlai Triglia |Alexandra Schnell |Toni Delorey |Kanishka Mohib |Christopher J. Giuliano | +11 more

AbstractThe role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth1,2. Here, using high-throughput flow cytometry as well as bulk and single-cell RNA-sequencing and B-cell-receptor-sequencing analysis of B cells temporally during B16F10 melanoma growth, we identified a subset of B cells that expands specifically in the draining lymph node over time in tumour-bearing mice.