Ana Alcaina-Caro

Mar 20, 2024 | nature.com | Zhuoxin Chen |Valentina Snetkova |Benjamin Clock |Iros Barozzi |Brandon J. Mannion |Ana Alcaina-Caro | +3 more

AbstractRemote enhancers are thought to interact with their target promoters via physical proximity, yet the importance of this proximity for enhancer function remains unclear. Here we investigate the three-dimensional (3D) conformation of enhancers during mammalian development by generating high-resolution tissue-resolved contact maps for nearly a thousand enhancers with characterized in vivo activities in ten murine embryonic tissues.