Zhuoxin Chen

Apr 24, 2024 | nature.com | Jorge Moreno |Olga Dudchenko |Charles Y. Feigin |Sarah A. Mereby |Zhuoxin Chen |Raul Ramos | +7 more

AbstractPhenotypic variation among species is a product of evolutionary changes to developmental programs1,2. However, how these changes generate novel morphological traits remains largely unclear. Here we studied the genomic and developmental basis of the mammalian gliding membrane, or patagium—an adaptative trait that has repeatedly evolved in different lineages, including in closely related marsupial species.

Mar 20, 2024 | nature.com | Zhuoxin Chen |Valentina Snetkova |Benjamin Clock |Iros Barozzi |Brandon J. Mannion |Ana Alcaina-Caro | +3 more

AbstractRemote enhancers are thought to interact with their target promoters via physical proximity, yet the importance of this proximity for enhancer function remains unclear. Here we investigate the three-dimensional (3D) conformation of enhancers during mammalian development by generating high-resolution tissue-resolved contact maps for nearly a thousand enhancers with characterized in vivo activities in ten murine embryonic tissues.