Andrea Marzi

Oct 10, 2024 | nature.com | Andrea Marzi |Heinz Feldmann

AbstractNowadays, filovirus vaccine development may be seen as a paradigm for our response capabilities to emerging and re-emerging infectious diseases. Specifically, the West African Ebola virus disease (EVD) epidemic accelerated countermeasure licensure for several vaccine and therapeutic products. Those products have been successfully used to control EVD outbreaks in Central Africa over the past years. This positive development, however, has not yet reached beyond EVD.

Apr 21, 2024 | cell.com | Alexandra Schafer |Andrea Marzi |Wakako Furuyama |Nicholas J. Catanzaro

Highlights•CC genetic reference population identifies genetic loci regulating EBOV pathogenesis in mice•An F2 population from two CC lines is either highly resistant or vulnerable to EBOV infection•A major locus on chromosome 7, encoding Trim5, drives severe EVD-like disease in mice•Gene expression signatures of liver damage mirror severe EVD in humansSummaryEbola virus (EBOV), a major global health concern, causes severe, often fatal EBOV disease (EVD) in humans.