Wakako Furuyama

Apr 21, 2024 | cell.com | Alexandra Schafer |Andrea Marzi |Wakako Furuyama |Nicholas J. Catanzaro

Highlights•CC genetic reference population identifies genetic loci regulating EBOV pathogenesis in mice•An F2 population from two CC lines is either highly resistant or vulnerable to EBOV infection•A major locus on chromosome 7, encoding Trim5, drives severe EVD-like disease in mice•Gene expression signatures of liver damage mirror severe EVD in humansSummaryEbola virus (EBOV), a major global health concern, causes severe, often fatal EBOV disease (EVD) in humans.