Nicholas J. Catanzaro

Dec 6, 2024 | cell.com | Kaitlin R Sprouse |Marcos Miranda |Nicholas J. Catanzaro |Amin Addetia |Cameron Stewart |Jack Brown | +19 more

KeywordsMERS-CoVEMPEMnanoparticlevaccineRBDNTDspikeResearch topic(s)CP: ImmunologyIntroductionThe recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has demonstrated the human and economic toll that can accompany the spillover and spread of a zoonotic disease in humans. Although the success of vaccine development efforts in response to the pandemic were a triumph of modern vaccinology, SARS-CoV-2 remains the only coronavirus for which licensed vaccines are available.

Apr 21, 2024 | cell.com | Alexandra Schafer |Andrea Marzi |Wakako Furuyama |Nicholas J. Catanzaro

Highlights•CC genetic reference population identifies genetic loci regulating EBOV pathogenesis in mice•An F2 population from two CC lines is either highly resistant or vulnerable to EBOV infection•A major locus on chromosome 7, encoding Trim5, drives severe EVD-like disease in mice•Gene expression signatures of liver damage mirror severe EVD in humansSummaryEbola virus (EBOV), a major global health concern, causes severe, often fatal EBOV disease (EVD) in humans.