Andreas Behren

Jul 16, 2024 | nature.com | Thomas S. Fulford |Marc Rigau |Amy Chung |Michael Parker |Andreas Behren |Nicholas A. Gherardin | +1 more

AbstractButyrophilin (BTN) molecules are emerging as key regulators of T cell immunity; however, how they trigger cell-mediated responses is poorly understood. Here, the crystal structure of a gamma-delta T cell antigen receptor (γδTCR) in complex with BTN2A1 revealed that BTN2A1 engages the side of the γδTCR, leaving the apical TCR surface bioavailable. We reveal that a second γδTCR ligand co-engages γδTCR via binding to this accessible apical surface in a BTN3A1-dependent manner.

Sep 15, 2023 | frontiersin.org | Andreas Behren |Raheleh Roudi |Hongwei Cheng

1 IntroductionGastric cancer (GC) is the fifth most common cancer and the fourth leading cause of cancer-related mortality in the world (1). Although fluoropyrimidines and platinum-based chemotherapy as first-line therapy and taxanes plus ramucirumab as second-line therapy are standard treatment for GC, prognosis remains poor and median survival is approximately one year (2–5).